Kratos: A new paradigm in Bioinformatics
Smpl Bio is creating a new bioinformatics platform technology, Kratos. Kratos will empower researchers in their quest to not only mine data from an experiment, but to also analyze data, seek valuable information, and gain incremental knowledge. Researchers will not have to seek unfamiliar software tools, or contemplate switching them for different phases of their research, or worry about setting complicated statistical parameters or try to figure out how to export data from one software tool to another – Kratos does it all, a conduit that takes in raw data and yields information and knowledge while being seamlessly integrated in the experimental workflow. Kratos is designed for the researcher / clinician yet has the computing power and superior analytics to fully satisfy a bioinformatician.
Unprecedented ease of use: No building pipelines, no online coding – unless you want
Just take the raw data, drag and click it to the Kratos icon. Kratos automatically deciphers the format, knows what to process and delivers fast and rapid analytics. Complex tasks such as data filtering, feature selection, model selection, parametrization, cross-validation, biomarker selection are implemented in a fast and automated fashion. And if the need is to solely perform a modest data analysis, Kratos will do that too!
Superior Analytics: Dynamic exhaustive exploration
The algorithms activated to sort, group, and classify data are extracted in real time, off a repository that stores all published or validated algorithms. The Kratos repository is continually updated with new algorithms, thereby allowing access to the ‘best-in-class’ algorithms, at all times. Based on the biological context or the experimental hypothesis, this repository is queried, and the experimental data is subjected to a series of rapid analytical tests. No more being restricted to a favorite algorithm, or being limited to a-priori algorithms in a software package, or being chained to an algorithm that is unsuitable for the preferred experiment or hypothesis.
Rigorous Quality: At every step
Qualification of data, prior to its inclusion or exclusion for sorting, grouping and classification is critical. Improper inclusion or exclusion of data elements, as is the case when employing subjectivity, could lead to severely different grouping outcomes, resulting in compromised analyses. Kratos takes out the subjectivity, by performing several computations to determine statistical and biological quality metrics. Kratos offers unmatched sorting, grouping and classification of data to provide superior analytics. Of course, all this happens ‘under the hood, ’ in a completely automated manner.
Biomarker Selection: Towards targeted ‘omics
Although Biomarkers are envisioned to fuel the personalized medicine revolution, the discovery and proper utilization of informative biomarkers remains a daunting experimental, statistical and informatics challenge. Kratos is a powerful discovery and analysis tool that is capable of seamlessly integrating with existing next-generation ‘omics platforms to extract informative biomarkers from very large and complex data sets. Kratos addresses the three core challenges of utilizing ‘omics data to advance personalized medicine:
A machine-learning pipeline is implemented to evaluate the performance of biomarker selection and predictive analysis algorithms on a wide variety of data types.
Kratos: The bioinformatics ecosystem
For a researcher the quest to mine data and analyze it, is habitually linked to acquiring information and gaining knowledge. In the informatics vernacular, this undertaking is often referred to as a sequence primary analysis, secondary analysis and tertiary analysis. Each of these sub-analyses, have been overwhelming for a life science researcher, given the highly disjointed effort and workflow necessitated by a plethora of computational software tools. It is no surprise that a continuum of primary, secondary, and tertiary analysis compounds the problems experienced with any sub-analysis, and despite being highly desirable is downright intimidating and for all practical purposes currently unachievable for the life science researcher. Kratos is a plug and play platform: it is being designed to seamlessly integrate with different hardware platforms and enables easy, rapid yet very powerful navigation through primary, secondary and tertiary analyses.